Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Arrhythmogenic Right Ventricular Cardiomyopathy, or ARVC, is an inherited condition that affects the muscles of the heart. ARVC is associated with sudden cardiac death and congestive heart failure. It is thought that these are a symptom of irregular heartbeats.
Dogs affected by ARVC typically begin showing symptoms around 6 years of age, however, this can vary widely. The best method to detect the symptoms of ARVC is through the use of a Holter monitor, in which the dog's health ECG is monitored for 24 hours, detecting any abnormalities such as ventricular premature complexes (VPCs) that may suggest ARVC.
Currently, there is one known mutation that is highly associated with ARVC. Testing for the mutation is a helpful tool, however, it is important to note that this mutation is not necessarily definitive. There are other unknown mutations responsible for ARVC in a smaller percent of the population, so a negative result does not ensure that the dog will not be affected. This is particularly true is the parents of a dog also test negative but experience symptoms. Additionally, dogs that test positive for ARVC will not necessarily experience symptoms, they are just at a substantially higher risk for developing the disease. Dogs that do test positive should report these results to their veterinarian; proper veterinary care can help manage the condition and promote a healthy life for the dog.
Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.
Test Is Relevant to the Following Breeds:
Animal Genetics offers DNA testing for Arrhythmogenic Right Ventricular Cardiomyopathy. The genetic test verifies the presence of the known ARVC mutation and presents results as one of the following:
|A/A||At Risk||The dog carries two copies of the mutant gene and is homozygous for the mutation associated with ARVC and will always pass a copy of the mutation to its offspring.|
|A/n||At Risk||Both the normal and mutant copies of the gene detected. Dog is a carrier for the ARVC mutation and can pass on a copy of the defective gene to its offspring.|
|n/n||Clear||Dog tested negative for the ARVC mutation and will not pass on the defective gene to its offspring.|