Factor VII Deficiency (FVII)

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Factor VII Deficiency (FVII)

Description:

Factor VII (FVII) Deficiency is a disorder that can cause excessive bleeding. Dogs affected by Factor VII Deficiency do not make enough Factor VII protein, which is an essential part of the blood coagulation process. As a result, an affected dog may blood excessively after an injury or surgery.


Affected dogs may not exhibit any symptoms normally; often the condition is not detected until the dog experiences an injury or after a medical procedure. In these circumstances, the dog may require a transfusion, however, the condition is typically not fatal with medical intervention.

 

The mutation is an autosomal recessive trait, so a dog who is a "carrier" of the mutation (has one copy of defective gene) may or may not pass on the mutation to its offspring.
Carriers are generally asymptomatic, and even "affected" dogs (have two copies of defective gene) may exhibit mild or no symptoms. It is therefore useful to test for the presence of the mutation before breeding.

Sample Type:

Animal Genetics accepts buccal swab, blood, dewclaw. Collection kits are available and can be ordered at test now.

Test Is Relevant to the Following Breeds:

Airedale, Alaskan Klee Kai, Beagle, Giant Schnauzer and Scottish Deerhound

Results:

Animal Genetics offers DNA testing for Factor VII (FVII). The genetic test verifies the presence of the recessive mutation and presents results as one of the following:

FVII/FVII Affected The dog carries two copies of the mutant gene and is homozygous for FVII. This dog will be affected and will always pass a copy of the mutated gene to its offspring.
FVII/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the FVII mutation and can pass on a copy of the defective gene to its offspring 50% 0f the time.
n/n Clear Dog tested negative for the FVII gene mutation and will not pass on the defective gene to its offspring.